Recombinant human erythropoietin (rHuEPO): Cross-linking with disuccinimidyl esters and identification of the interfacing domains in EPO
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منابع مشابه
Effects of Recombinant Human Erythropoietin (rHuEpo) on the Blood Cells and Hematopoiesis in Spleen of Rats
Recombinant human erythropoietin is a glycoprotein hormone that stimulates erythropoiesis. In clonogenic assays of hematopoietic progenitors, high concen-trations of erythropoietin (Epo) increase CFU-E and diminish the number of granulocytes formed per culture plate. Fetal progenitors are more sensitive to these effects of Epo than progenitors from adults. We administered doses 50, 100, 200 IU/...
متن کاملThe effect of recombinant human erythropoietin (rHuEpo) on blood cells of adult and immature rats
Human recombinant erythropoietin is a synthetic hormone for treatment of some kinds of anemia. In this study, the effect of this hormone was investigated on blood cell changes in adult and immature rats. For this purpose, the hormone was administered at doses of 50, 100, and 200 IU/Kg (s.c.) twice a week for a period of 6 weeks. Then, the number of red blood cells (RBC), subtypes of white blood...
متن کاملThe Effects of Recombinant Human Erythropoietin (rHuEPO) on Antihuman Lymphocyte Antibodies Titer in Sensitized Rats
Erythropoietin (EPO) was first known as a factor for red blood cell proliferation and differentiation. Recent studies show the effects of EPO on immune system. In this study the antihuman leukocyte antibody (anti-HLA) titer were determined in five groups of rats, which had been sensitized with human lymphocyte. Also, the effects of stimulation's frequency and dose of recombinant human erythropo...
متن کاملeffects of recombinant human erythropoietin (rhuepo) on the blood cells and hematopoiesis in spleen of rats
recombinant human erythropoietin is a glycoprotein hormone that stimulates erythropoiesis. in clonogenic assays of hematopoietic progenitors, high concen-trations of erythropoietin (epo) increase cfu-e and diminish the number of granulocytes formed per culture plate. fetal progenitors are more sensitive to these effects of epo than progenitors from adults. we administered doses 50, 100, 200 iu/...
متن کاملEffects of Recombinant Human Erythropoietin Pretreatment on Anti-HLA Antibody Titer: A Preclinical Experience in Rats
Background: Erythropoietin (EPO) was first known as a factor for red blood cell proliferation and differentiation. New studies show the effects of EPO on immune system. Objective: In this study, the effects of pretreatment with recombinant human erythropoietin (rHuEPO) on the anti-human leukocyte antibody (anti-HLA) titer were determined. Methods: Three groups of rats were sensitized with human...
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ژورنال
عنوان ژورنال: Protein Science
سال: 1993
ISSN: 0961-8368,1469-896X
DOI: 10.1002/pro.5560020908